Publications

2016

Chinen AB, Ferrer JR, Merkel TJ, Mirkin CA. Relationships between Poly(ethylene glycol) Modifications on RNA-Spherical Nucleic Acid Conjugates and Cellular Uptake and Circulation Time. Bioconjug Chem. 2016 Oct 20. [Epub ahead of print] PMID: 27762539

Savaryn JP, Toby TK, Kelleher NL. A researcher’s guide to mass spectrometry-based proteomics. Proteomics. 2016 Sep;16(18):2435-43. doi: 10.1002/pmic.201600113. PMID: 27553853

Goering AW, Li J, McClure RA, Thomson RJ, Jewett MC, Kelleher NL. In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis. ACS Synth Biol. 2016 Aug 9. [Epub ahead of print] PMID: 27478992

Henke MT, Soukup AA, Goering AW, McClure RA, Thomson RJ, Keller NP, Kelleher NL. New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans. ACS Chem Biol. 2016 Aug 19;11(8):2117-23. doi: 10.1021/acschembio.6b00398. PMID: 27310134

Kathman SG, Statsyuk AV. Covalent Tethering of Fragments For Covalent Probe Discovery. Medchemcomm. 2016 Apr 1;7(4):576-585. PMID: 27398190

Toby TK, Fornelli L, Kelleher NL. Progress in Top-Down Proteomics and the Analysis of Proteoforms. Annu Rev Anal Chem (Palo Alto Calif). 2016 Jun 12;9(1):499-519. doi: 10.1146/annurev-anchem-071015-041550. PMID: 27306313

Savaryn JP, Toby TK, Catherman AD, Fellers RT, LeDuc RD, Thomas PM, Friedewald JJ, Salomon DR, Abecassis MM, Kelleher NL. Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection. Proteomics. 2016 Jul;16(14):2048-58. doi: 10.1002/pmic.201600008. PMID:27120713

Goering AW, McClure RA, Doroghazi JR, Albright JC, Haverland NA, Zhang Y, Ju KS, Thomson RJ, Metcalf WW, Kelleher NL. Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. ACS Cent Sci. 2016 Feb 24;2(2):99-108. doi: 10.1021/acscentsci.5b00331. PMID: 27163034

Ntai I, Toby TK, LeDuc RD, Kelleher NL. A Method for Label-Free, Differential Top-Down Proteomics. Methods Mol Biol. 2016;1410:121-33. doi: 10.1007/978-1-4939-3524-6_8. PMID: 26867742

Chen Y, McClure RA, Kelleher NL. Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics. Methods Mol Biol. 2016;1401:135-47. doi: 10.1007/978-1-4939-3375-4_9. PMID: 26831706

 

2015

Damon PL, Liss CJ, Lewis RA, Morochnik S, Szpunar DE, Telser J, Hayton TW. Quantifying the Electron Donor and Acceptor Abilities of the Ketimide Ligands in M(N═C(t)Bu2)4 (M = V, Nb, Ta). Inorg Chem. 2015 Oct 19;54(20):10081-95. doi: 10.1021/acs.inorgchem.5b02017. PMID: 26419513

McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4509-12. doi: 10.1016/j.bmcl.2015.08.074. PMID: 26342866

Chinen AB, Guan CM, Ferrer JR, Barnaby SN, Merkel TJ, Mirkin CA. Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence. Chem Rev. 2015 Oct 14;115(19):10530-74. doi: 10.1021/acs.chemrev.5b00321. Review. PMID:26313138

Kathman SG, Span I, Smith AT, Xu Z, Zhan J, Rosenzweig AC, Statsyuk AV. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 7;137(39):12442-5. doi: 10.1021/jacs.5b06839. PMID: 26371805

Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics. EuPA Open Proteom. 2015 Sep;8:40-47. PMID: 26753126

Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K. T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunol Res. 2015 Jul;3(7):806-14. doi: 10.1158/2326-6066.CIR-14-0169. PMID: 25855122

Wu HC, Yamankurt G, Luo J, Subramaniam J, Hashmi SS, Hu H, Cunha SR. Identification and characterization of two ankyrin-B isoforms in mammalian heart. Cardiovasc Res. 2015 Sep 1;107(4):466-77. doi: 10.1093/cvr/cvv184. Epub 2015 Jun 24.

Albright JC, Henke MT, Soukup AA, McClure RA, Thomson RJ, Keller NP, Kelleher NL. Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation. ACS Chem Biol. 2015 Jun 19;10(6):1535-41. doi: 10.1021/acschembio.5b00025. PMID: 25815712

Ferrer JR, Chokechanachaisakul A, Wertheim JA. New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases. Curr Transplant Rep. 2015 Jun 1;2(2):202-210. PMID: 26317066

Yamankurt G, Wu HC, McCarthy M, Cunha SR. Exon organization and novel alternative splicing of Ank3 in mouse heart. PLoS One. 2015 May 29;10(5):e0128177. doi: 10.1371/journal.pone.0128177. eCollection 2015.

Kalman, R., Subramanian, H., Nunes, D., DeLaCruz, M., Wali, R.K., Jepeal, L.I., Stawarz, A., Zhang, D., Backman, V., and Hemant, H.K. 951 Biophonotic Detection of High Order Chromatin Alterations in Field Carcinogenesis Predicts Risk of Future Hepatocellular Carcinoma: A Pilot Study. Gastroenterology 148.4 (2015): S-184. April 2015Volume 148, Issue 4, Supplement 1, Pages S-184–S-185

Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O’Halloran TV. Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nat Chem. 2015 Feb;7(2):130-9. doi: 10.1038/nchem.2133. PMID: 25615666

 

2014

Boehler RM, Kuo R, Shin S, Goodman AG, Pilecki MA, Gower RM, Leonard JN, Shea LD. Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype. Biotechnol Bioeng. 2014 Jun;111(6):1210-21. doi: 10.1002/bit.25175. Erratum in: Biotechnol Bioeng. 2014 Jul;111(7):1469. Gower, R M [added]. PMID: 24375008

Kathman SG, Xu Z, Statsyuk AV. A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem. 2014 Jun 12;57(11):4969-74. doi: 10.1021/jm500345q. PMID: 24870364

 

2013

Ye H, Toby TK, Sommers CD, Ghasriani H, Trehy ML, Ye W, Kolinski RE, Buhse LF, Al-Hakim A, Keire DA. Characterization of currently marketed heparin products: key tests for LMWH quality assurance. J Pharm Biomed Anal. 2013 Nov;85:99-107. doi: 10.1016/j.jpba.2013.06.033. PMID: 23917037

Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K. Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res. 2013 Oct 1;73(19):5905-13. doi: 10.1158/0008-5472.CAN-13-1511. PMID: 23955389

Chen Y, McClure RA, Zheng Y, Thomson RJ, Kelleher NL. Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase. J Am Chem Soc. 2013 Jul 17;135(28):10449-56. doi: 10.1021/ja4031193. PMID:23763305

Chen Y, Unger M, Ntai I, McClure RA, Albright JC, Thomson RJ, Kelleher NL. Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics. Medchemcomm. 2013 Jan 1;4(1):233-238. PMID:23336063